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BOOK SUMMARY :

Dendritic cells dcs are central regulators of the adaptive immune response and as such are necessary for t cell mediated cancer immunity in particular antitumoral responses depend on a specialized subset of conventional dcs that transport tumor antigens to draining lymph nodes and cross present antigen to activate cytotoxic t lymphocytesdysfunctional dendritic cells in cancer tumors that progress do so via their ability to escape the anti tumor immune response through several mechanisms including developing ways to impair functional differentiation and activation of dcssince the mid 1990s dendritic cells have been used in clinical trials as cellular mediators for therapeutic vaccination of patients with cancer dendritic cell based immunotherapy is safe and can induce antitumour immunity even in patients with advanced disease however clinical responses have been disappointing with classic objective tumour response rates rarely exceeding 15dendritic cells dcs are powerful antigen presenting cells for the induction of antigen specific t cell response dc vaccine has been introduced as a new therapeutic strategy in cancer patients dc based immunotherapy is safe and can promote antitumor immune responses and prolonged survival of cancer patientsdendritic cells dc have been tested in cancer immunotherapy clinical trials for two decades over this time the methods of dc culture or manufacture have evolved the approaches for antigen loading have broadened the maturation signals have varied and different sites of administration have been tested

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