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BOOK SUMMARY :

1 introduction the use of non animal test methods including computer based approaches and in vitro studies provides important tools to enhance our understanding of hazardous effects by chemicals and for predicting these effects on humans broadhead and combes 2001in vitro systems are used principally for screening purposes and for generating more comprehensive toxicological profilesin vitro methods in toxicology is a chapter from a textbook in press by academic press toxicology is scheduled for publication in 1999 during the last century the field of toxicology has evolved from one of describing the consequences of exposure to chemicals to xenobiotics in animals to mechanistically based studies of both animals and first published in 1987 this book describes tissue cell and organ culture techniques which could be used at a critical predevelopment stage to screen for drug inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studiesthe development of alternative methods to animal experimentation has progressed rapidly over the last 20 years today in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds advanced alternative methods and their first published in 1987 this book describes tissue cell and organ culture techniques which could be used at a critical predevelopment stage to screen for drug inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studies this type of research has important ethical financial and scientific implications

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